CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04193
Pert ID:	BRD-K96319534
Compound Name:	phentermine
Targets:	MAOA\|MAOB\|SLC6A2\|SLC6A3\|SLC6A4
MoA:	dopamine uptake inhibitor; serotonin reuptake inhibitor
SMILES:	CC(C)(N)Cc1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5703	BRD-K96319534	HCC515	10 uM	24 h	-0.3	-1.25	0.71	-0.3	-1.01	0.56
6408	BRD-K96319534	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.99	0.51
37770	BRD-K96319534	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37965	BRD-K96319534	HEPG2	10 uM	6 h	0.22	0.91	0.03	-0.26	-0.86	0.22
38581	BRD-K96319534	NPC	10 uM	24 h	0.24	0.99	0.1	0.29	1.03	0.52
96471	BRD-K96319534	A375	1.11 uM	24 h	0.24	0.98	0.09	0.0	0.0	0.0
96537	BRD-K96319534	PC3	1.11 uM	24 h	0.21	0.87	0.01	0.0	0.0	0.0
128136	BRD-K96319534	A549	0.125 uM	24 h	0.24	0.99	0.1	0.0	0.0	0.0
128217	BRD-K96319534	MCF10A	0.04 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.7
128296	BRD-K96319534	MDAMB231	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128350	BRD-K96319534	THP1	0.04 uM	24 h	0.24	1.02	0.12	0.23	0.8	0.08
135806	BRD-K96319534	HA1E	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135847	BRD-K96319534	HEK293	0.01 uM	24 h	0.0	0.0	0.0	-0.35	-1.19	1.15
135891	BRD-K96319534	HELA	0.08 uM	24 h	0.0	0.0	0.0	0.38	1.34	1.72
135937	BRD-K96319534	HT29	0.25 uM	24 h	0.25	1.04	0.15	0.0	0.0	0.0
135980	BRD-K96319534	JURKAT	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136026	BRD-K96319534	MCF??7.00	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136126	BRD-K96319534	YAPC	0.03 uM	24 h	0.0	0.0	0.0	-0.23	-0.78	0.09

Summary