CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04228
Pert ID:	BRD-K47642186
Compound Name:	piclamilast
Targets:	PDE4A\|PDE4B\|PDE4C\|PDE4D
MoA:	phosphodiesterase inhibitor
SMILES:	COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125238	BRD-K47642186	A375	1.11 uM	24 h	-0.28	-1.18	0.5	-0.37	-1.23	1.28
125278	BRD-K47642186	HA1E	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125310	BRD-K47642186	HEK293	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125397	BRD-K47642186	JURKAT	10 uM	24 h	0.31	1.31	0.75	0.24	0.84	0.13
125443	BRD-K47642186	MCF??7.00	3.33 uM	24 h	-0.2	-0.81	0.0	-0.35	-1.18	1.14
125516	BRD-K47642186	THP1	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133361	BRD-K47642186	A549	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133419	BRD-K47642186	HELA	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133452	BRD-K47642186	HT29	0.74 uM	24 h	0.0	0.0	0.0	0.35	1.25	1.29
133515	BRD-K47642186	MCF10A	0.01 uM	24 h	0.21	0.87	0.01	0.0	0.0	0.0
133552	BRD-K47642186	MDAMB231	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133581	BRD-K47642186	PC3	0.01 uM	24 h	-0.17	-0.72	0.0	0.0	0.0	0.0
133630	BRD-K47642186	YAPC	2.22 uM	24 h	0.0	0.0	0.0	-0.33	-1.11	0.9
136447	BRD-K47642186	SHSY5Y	10 uM	24 h	0.0	0.0	0.0	0.43	1.51	2.28

Summary