CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04250
Pert ID:	BRD-K83405785
Compound Name:	pimavanserin
Targets:	DRD2\|HTR2A
MoA:	serotonin receptor inverse agonist
SMILES:	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C)CC2)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125558	BRD-K83405785	A375	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125601	BRD-K83405785	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125624	BRD-K83405785	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125663	BRD-K83405785	HELA	0.04 uM	24 h	-0.26	-1.09	0.31	0.0	0.0	0.0
125687	BRD-K83405785	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125706	BRD-K83405785	HUVEC	10 uM	24 h	-0.22	-0.91	0.06	-0.32	-1.07	0.76
125814	BRD-K83405785	MCF??7.00	10 uM	24 h	-0.21	-0.88	0.03	0.0	0.0	0.0
125839	BRD-K83405785	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125861	BRD-K83405785	PC3	10 uM	24 h	0.0	0.0	0.0	0.3	1.05	0.57
125905	BRD-K83405785	YAPC	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133720	BRD-K83405785	HEK293	0.03 uM	24 h	0.16	0.68	0.0	0.0	0.0	0.0
133814	BRD-K83405785	JURKAT	2.22 uM	24 h	0.0	0.0	0.0	0.3	1.06	0.59
133839	BRD-K83405785	MCF10A	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133960	BRD-K83405785	THP1	2.22 uM	24 h	0.22	0.9	0.02	0.24	0.86	0.16

Summary