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CMap Candidate Details

Structure:
CMap ID: C04303
Pert ID: BRD-K75958195
Compound Name: pizotifen
Targets: HTR1A|HTR2A|HTR2C
MoA: serotonin receptor antagonist
SMILES: CN1CCC(CC1)=C1c2ccsc2CCc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5362 BRD-K75958195 HA1E 10 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
5684 BRD-K75958195 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6409 BRD-K75958195 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24477 BRD-K75958195 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25188 BRD-K75958195 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37309 BRD-K75958195 A549 10 uM 24 h -0.3 -1.26 0.72 0.0 0.0 0.0
37734 BRD-K75958195 ASC 10 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
37943 BRD-K75958195 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.28 0.98 0.39
38106 BRD-K75958195 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38551 BRD-K75958195 NPC 10 uM 24 h -0.25 -1.06 0.25 0.0 0.0 0.0
38775 BRD-K75958195 PHH 10 uM 24 h -0.22 -0.92 0.06 0.35 1.25 1.29
39001 BRD-K75958195 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52019 BRD-K75958195 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).