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CMap Candidate Details

Structure:
CMap ID: C04318
Pert ID: BRD-K16478699
Compound Name: PLX-4720
Targets: BRAF|KDR
MoA: RAF inhibitor
SMILES: CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
31285 BRD-K16478699 HEPG2 10 uM 6 h 0.24 1.02 0.12 -0.37 -1.24 1.35
34054 BRD-K16478699 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35739 BRD-K16478699 NPC 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.53
36212 BRD-K16478699 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36507 BRD-K16478699 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36950 BRD-K16478699 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91044 BRD-K16478699 HUH7 1.11 uM 72 h -0.29 -1.2 0.57 0.0 0.0 0.0
91537 BRD-K16478699 BT20 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.9
91618 BRD-K16478699 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91643 BRD-K16478699 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.15
91743 BRD-K16478699 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92163 BRD-K16478699 HS578T 1.11 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92316 BRD-K16478699 MDAMB231 0.12 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
96118 BRD-K16478699 A549 10 uM 24 h -0.26 -1.08 0.31 -0.27 -0.92 0.32
116673 BRD-K16478699 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116756 BRD-K16478699 HA1E 10 uM 24 h 0.25 1.03 0.13 -0.26 -0.89 0.26
116804 BRD-K16478699 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116895 BRD-K16478699 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116980 BRD-K16478699 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).