CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04330
Pert ID:	BRD-K47869605
Compound Name:	podophyllotoxin
Targets:	IGF1R\|TOP2A\|TUBA4A\|TUBB
MoA:	microtubule inhibitor; tubulin polymerization inhibitor
SMILES:	COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4225	BRD-K47869605	HA1E	10 uM	6 h	0.0	0.0	0.0	-0.29	-0.97	0.47
4439	BRD-K47869605	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37677	BRD-K47869605	ASC	10 uM	24 h	0.0	0.0	0.0	-0.25	-0.86	0.2
38501	BRD-K47869605	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38965	BRD-K47869605	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
50542	BRD-K47869605	HT29	10 uM	6 h	0.26	1.06	0.19	0.0	0.0	0.0
51035	BRD-K47869605	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.09	0.81
53455	BRD-K47869605	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
53591	BRD-K47869605	HUH7	2.5 uM	6 h	0.0	0.0	0.0	-0.43	-1.45	15.35
53669	BRD-K47869605	PHH	10 uM	24 h	0.0	0.0	0.0	0.35	1.25	1.28
96610	BRD-K47869605	A375	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99583	BRD-K47869605	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
125749	BRD-K47869605	HUVEC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125808	BRD-K47869605	MCF10A	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125856	BRD-K47869605	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125880	BRD-K47869605	PC3	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125947	BRD-K47869605	YAPC	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133674	BRD-K47869605	A549	0.74 uM	24 h	-0.24	-0.99	0.14	0.0	0.0	0.0
133740	BRD-K47869605	HEK293	0.01 uM	24 h	0.0	0.0	0.0	-0.39	-1.32	1.71
133776	BRD-K47869605	HELA	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133833	BRD-K47869605	JURKAT	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133892	BRD-K47869605	MCF??7.00	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133987	BRD-K47869605	THP1	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary