CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04351
Pert ID:	BRD-K67537649
Compound Name:	PQ-401
Targets:	IGF1R
MoA:	IGF-1 inhibitor
SMILES:	COc1ccc(Cl)cc1NC(=O)Nc1cc(C)nc2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4236	BRD-K67537649	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
4464	BRD-K67537649	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
4706	BRD-K67537649	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
4951	BRD-K67537649	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.99	0.51
39474	BRD-K67537649	A549	10 uM	6 h	0.21	0.87	0.01	0.0	0.0	0.0
39743	BRD-K67537649	ASC	10 uM	24 h	0.22	0.9	0.03	0.0	0.0	0.0
40037	BRD-K67537649	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.32	-1.08	0.81
40306	BRD-K67537649	HT29	10 uM	6 h	0.0	0.0	0.0	0.28	0.99	0.4
40494	BRD-K67537649	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.45	-1.53	15.35
40849	BRD-K67537649	NEU	10 uM	24 h	-0.29	-1.21	0.58	-0.34	-1.14	1.02
41160	BRD-K67537649	NPC	10 uM	24 h	0.0	0.0	0.0	-0.35	-1.19	1.16
41498	BRD-K67537649	SKB	10 uM	24 h	0.24	1.01	0.12	0.0	0.0	0.0
97292	BRD-K67537649	HAP1	3.33 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.69
97346	BRD-K67537649	A375	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99370	BRD-K67537649	U2OS	10 uM	6 h	0.26	1.09	0.24	0.0	0.0	0.0

Summary