CMap Candidate Details
Structure:
| CMap ID: | C04445 |
| Pert ID: | BRD-K79116891 |
| Compound Name: | proxymetacaine |
| Targets: | SCN10A|SCN5A |
| MoA: | sodium channel blocker |
| SMILES: | CCCOc1ccc(cc1N)C(=O)OCCN(CC)CC |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1631 | BRD-K79116891 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.99 | 0.5 |
| 1976 | BRD-K79116891 | HCC515 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2684 | BRD-K79116891 | VCAP | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.33 | -1.1 | 0.88 |
| 39179 | BRD-K79116891 | A375 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.25 | 0.89 | 0.21 |
| 39768 | BRD-K79116891 | ASC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 40063 | BRD-K79116891 | HEPG2 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.23 | 0.82 | 0.1 |
| 40326 | BRD-K79116891 | HT29 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.34 | -1.15 | 1.07 |
| 40869 | BRD-K79116891 | NEU | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.33 | -1.12 | 0.93 |
| 41187 | BRD-K79116891 | NPC | 10 uM | 24 h | -0.23 | -0.94 | 0.08 | -0.34 | -1.13 | 0.98 |
| 41526 | BRD-K79116891 | SKB | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.3 | -1.0 | 0.53 |
| 50055 | BRD-K79116891 | A549 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 52197 | BRD-K79116891 | MCF??7.00 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.28 | 0.97 | 0.36 |
| 52337 | BRD-K79116891 | PC3 | 10 uM | 24 h | -0.29 | -1.2 | 0.55 | 0.0 | 0.0 | 0.0 |