CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04447
Pert ID:	BRD-K25835157
Compound Name:	PRT062070
Targets:	SYK
MoA:	JAK inhibitor; syk inhibitor
SMILES:	CCS(=O)(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
87293	BRD-K25835157	BJAB	2.5 uM	24 h	0.0	0.0	0.0	0.28	1.0	0.43
87378	BRD-K25835157	HBL1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87427	BRD-K25835157	K562	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87475	BRD-K25835157	KMS34	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87531	BRD-K25835157	MINO	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
87579	BRD-K25835157	NALM6	2.5 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87630	BRD-K25835157	OCILY10	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87679	BRD-K25835157	OCILY19	2.5 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87731	BRD-K25835157	OCILY3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87778	BRD-K25835157	SKMEL5	2.5 uM	24 h	0.0	0.0	0.0	0.29	1.04	0.54
87809	BRD-K25835157	THP1	10 uM	3 h	-0.23	-0.95	0.09	0.0	0.0	0.0
87858	BRD-K25835157	TMD8	2.5 uM	3 h	0.0	0.0	0.0	0.37	1.32	1.6
98006	BRD-K25835157	HA1E	3.33 uM	24 h	0.23	0.94	0.06	-0.29	-0.98	0.47
98040	BRD-K25835157	MCF??7.00	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
98093	BRD-K25835157	P1A82	1.11 uM	24 h	-0.22	-0.92	0.06	0.0	0.0	0.0

Summary