CMap Candidate Details
Structure:
| CMap ID: | C00446 |
| Pert ID: | BRD-K95260951 |
| Compound Name: | asenapine |
| Targets: | ADRA1A|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|DRD1|DRD2|DRD3|DRD4|HRH1|HRH2|HTR1A|HTR1B|HTR1D|HTR1E|HTR2A|HTR2B|HTR2C|HTR5A|HTR6|HTR7 |
| MoA: | dopamine receptor antagonist; serotonin receptor antagonist |
| SMILES: | CN1C[C@H]2[C@H](C1)c1cc(Cl)ccc1Oc1ccccc21 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 128386 | BRD-K95260951 | A549 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128441 | BRD-K95260951 | HEK293 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128480 | BRD-K95260951 | HELA | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128551 | BRD-K95260951 | JURKAT | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128595 | BRD-K95260951 | MCF10A | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128643 | BRD-K95260951 | MDAMB231 | 0.125 uM | 24 h | -0.19 | -0.8 | 0.0 | -0.24 | -0.79 | 0.11 |
| 128723 | BRD-K95260951 | THP1 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.24 | -0.81 | 0.13 |
| 128769 | BRD-K95260951 | YAPC | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 136183 | BRD-K95260951 | A375 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 136227 | BRD-K95260951 | HA1E | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 136292 | BRD-K95260951 | HT29 | 0.03 uM | 24 h | 0.19 | 0.78 | 0.0 | 0.0 | 0.0 | 0.0 |
| 136345 | BRD-K95260951 | MCF??7.00 | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.32 | -1.08 | 0.79 |
| 136366 | BRD-K95260951 | PC3 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |