Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C04485
Pert ID: BRD-K01567962
Compound Name: pyrazolanthrone
Targets: MAPK10|MAPK8|MAPK8IP1|MAPK9|TTK
MoA: JNK inhibitor
SMILES: O=C1c2ccccc2-c2n[nH]c3cccc1c23
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2827 BRD-K01567962 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3129 BRD-K01567962 HCC515 10 uM 24 h -0.3 -1.25 0.71 -0.28 -0.94 0.38
3935 BRD-K01567962 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.12 0.96
41368 BRD-K01567962 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91791 BRD-K01567962 HS578T 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91887 BRD-K01567962 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91953 BRD-K01567962 SKBR3 10 uM 6 h -0.3 -1.25 0.7 -0.36 -1.2 1.22
94508 BRD-K01567962 ASC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94538 BRD-K01567962 CD34 10 uM 24 h -0.31 -1.29 0.77 -0.27 -0.92 0.32
94629 BRD-K01567962 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94681 BRD-K01567962 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94732 BRD-K01567962 HME1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94783 BRD-K01567962 HT29 0.37 uM 24 h 0.29 1.23 0.5 -0.32 -1.09 0.83
94826 BRD-K01567962 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94878 BRD-K01567962 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
94926 BRD-K01567962 MCF10A 1.11 uM 24 h -0.19 -0.78 0.0 0.31 1.08 0.65
95005 BRD-K01567962 NEU 0.04 uM 24 h -0.24 -1.0 0.15 -0.27 -0.91 0.29
95070 BRD-K01567962 NPC 10 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.49
95151 BRD-K01567962 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95201 BRD-K01567962 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95263 BRD-K01567962 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95821 BRD-K01567962 A375 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95879 BRD-K01567962 MCF??7.00 25 uM 6 h 0.0 0.0 0.0 -0.27 -0.92 0.33
95901 BRD-K01567962 YAPC 25 uM 6 h 0.0 0.0 0.0 0.25 0.88 0.19
95949 BRD-K01567962 A549 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95962 BRD-K01567962 PC3 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
99961 BRD-K01567962 U2OS 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
115447 BRD-K01567962 HEPG2 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).