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CMap Candidate Details

Structure:
CMap ID: C04517
Pert ID: BRD-K59632282
Compound Name: quinidine
Targets: KCNA5|KCNA7|KCNH1|KCNH2|KCNH5|KCNK1|KCNK6|SCN5A|SLC29A4
MoA: sodium channel blocker
SMILES: COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CC[N@]3C[C@@H]4C=C)c2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4449 BRD-K59632282 HCC515 10 uM 24 h -0.3 -1.26 0.73 0.27 0.94 0.3
4943 BRD-K59632282 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37404 BRD-K59632282 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37704 BRD-K59632282 ASC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.98
37927 BRD-K59632282 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38525 BRD-K59632282 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38754 BRD-K59632282 PHH 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
38980 BRD-K59632282 SKB 10 uM 24 h 0.24 0.99 0.09 0.0 0.0 0.0
123810 BRD-K59632282 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123918 BRD-K59632282 HEK293 10 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.93
123971 BRD-K59632282 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124020 BRD-K59632282 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.19
124071 BRD-K59632282 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124102 BRD-K59632282 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124138 BRD-K59632282 MDAMB231 10 uM 24 h 0.2 0.84 0.0 0.24 0.85 0.14
124201 BRD-K59632282 THP1 10 uM 24 h -0.28 -1.16 0.47 0.0 0.0 0.0
124254 BRD-K59632282 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132175 BRD-K59632282 HA1E 0.03 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
132206 BRD-K59632282 HELA 0.01 uM 24 h 0.28 1.15 0.32 0.3 1.07 0.63
132309 BRD-K59632282 PC3 0.74 uM 24 h 0.0 0.0 0.0 -0.21 -0.7 0.03
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).