CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04551
Pert ID:	BRD-A97674275
Compound Name:	ranolazine
Targets:	SCN10A\|SCN4A\|SCN5A\|SCN9A
MoA:	sodium channel blocker
SMILES:	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4325	BRD-A97674275	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
4867	BRD-A97674275	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
24739	BRD-A97674275	HA1E	10 uM	6 h	0.0	0.0	0.0	-0.47	-1.59	15.65
37570	BRD-A97674275	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37863	BRD-A97674275	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38409	BRD-A97674275	NPC	10 uM	24 h	-0.21	-0.87	0.02	0.0	0.0	0.0
38676	BRD-A97674275	PHH	10 uM	24 h	0.0	0.0	0.0	-0.3	-0.99	0.51
38899	BRD-A97674275	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91411	BRD-A97674275	HUH7	8 uM	72 h	-0.27	-1.11	0.37	0.25	0.89	0.21
128112	BRD-A97674275	A375	10 uM	24 h	0.25	1.05	0.16	0.0	0.0	0.0
128171	BRD-A97674275	HEK293	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128187	BRD-A97674275	HT29	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128229	BRD-A97674275	MCF10A	3.33 uM	24 h	-0.2	-0.84	0.01	0.0	0.0	0.0
128263	BRD-A97674275	MCF??7.00	10 uM	24 h	-0.19	-0.8	0.0	0.32	1.12	0.76
128308	BRD-A97674275	MDAMB231	3.33 uM	24 h	0.26	1.09	0.23	0.35	1.26	1.29
135779	BRD-A97674275	A549	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135903	BRD-A97674275	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135992	BRD-A97674275	JURKAT	0.03 uM	24 h	-0.31	-1.3	0.81	-0.35	-1.18	1.15
136063	BRD-A97674275	PC3	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136093	BRD-A97674275	THP1	2.22 uM	24 h	0.26	1.09	0.23	-0.23	-0.78	0.1
136138	BRD-A97674275	YAPC	0.74 uM	24 h	-0.25	-1.05	0.23	0.0	0.0	0.0

Summary