CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04562
Pert ID:	BRD-K85751432
Compound Name:	refametinib
Targets:	MAP2K1\|MAP2K2
MoA:	MEK inhibitor
SMILES:	COc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1NS(=O)(=O)C1(C[C@H](O)CO)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
95349	BRD-K85751432	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95425	BRD-K85751432	U2OS	10 uM	48 h	0.0	0.0	0.0	0.26	0.91	0.23
125572	BRD-K85751432	A375	3.33 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.41
125643	BRD-K85751432	HEK293	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125692	BRD-K85751432	HT29	0.37 uM	24 h	0.0	0.0	0.0	0.35	1.25	1.29
125721	BRD-K85751432	HUVEC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125867	BRD-K85751432	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125920	BRD-K85751432	YAPC	10 uM	24 h	0.0	0.0	0.0	0.36	1.26	1.29
133660	BRD-K85751432	A549	2.22 uM	24 h	0.0	0.0	0.0	0.37	1.3	1.59
133692	BRD-K85751432	HA1E	0.25 uM	24 h	0.29	1.2	0.42	0.22	0.79	0.07
133756	BRD-K85751432	HELA	2.22 uM	24 h	0.24	1.01	0.12	0.37	1.31	1.59
133821	BRD-K85751432	JURKAT	2.22 uM	24 h	0.22	0.91	0.03	-0.28	-0.93	0.35
133849	BRD-K85751432	MCF10A	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133905	BRD-K85751432	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133969	BRD-K85751432	THP1	2.22 uM	24 h	0.0	0.0	0.0	-0.25	-0.84	0.18

Summary