CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04564
Pert ID:	BRD-K16730910
Compound Name:	regorafenib
Targets:	ABL1\|BRAF\|DDR2\|EPHA2\|FGFR1\|FGFR2\|FLT1\|FLT4\|FRK\|KDR\|KIT\|MAPK11\|NTRK1\|PDGFRA\|PDGFRB\|RAF1\|RET\|TEK
MoA:	FGFR inhibitor; KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; RAF inhibitor; RET tyrosine kinase inhibitor; VEGFR inhibitor
SMILES:	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
90818	BRD-K16730910	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94461	BRD-K16730910	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94495	BRD-K16730910	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94570	BRD-K16730910	CD34	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94658	BRD-K16730910	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94765	BRD-K16730910	HME1	10 uM	24 h	0.0	0.0	0.0	0.36	1.28	1.41
94857	BRD-K16730910	HUVEC	10 uM	24 h	0.0	0.0	0.0	0.32	1.13	0.84
94907	BRD-K16730910	JURKAT	0.12 uM	24 h	0.0	0.0	0.0	-0.19	-0.64	0.01
95035	BRD-K16730910	NEU	10 uM	24 h	-0.2	-0.82	0.0	0.0	0.0	0.0
95061	BRD-K16730910	NPC	3.33 uM	24 h	0.32	1.35	0.93	0.0	0.0	0.0
95131	BRD-K16730910	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95183	BRD-K16730910	SHSY5Y	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95221	BRD-K16730910	SKL	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95292	BRD-K16730910	THP1	3.33 uM	24 h	-0.29	-1.19	0.53	0.0	0.0	0.0
95444	BRD-K16730910	U2OS	10 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
117004	BRD-K16730910	A375	3.33 uM	24 h	0.0	0.0	0.0	0.41	1.45	2.22
117119	BRD-K16730910	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.61
117171	BRD-K16730910	HEPG2	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
117215	BRD-K16730910	HT29	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120313	BRD-K16730910	HA1E	10 uM	24 h	0.0	0.0	0.0	0.34	1.22	1.15
120360	BRD-K16730910	HELA	3.33 uM	3 h	0.0	0.0	0.0	0.0	0.0	0.0
120403	BRD-K16730910	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120471	BRD-K16730910	YAPC	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.86	0.22

Summary