CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04571
Pert ID:	BRD-K82846253
Compound Name:	repaglinide
Targets:	ABCC8\|KCNJ11\|PPARG
MoA:	insulin secretagogue
SMILES:	CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
25048	BRD-K82846253	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
25536	BRD-K82846253	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
52340	BRD-K82846253	PC3	10 uM	24 h	0.0	0.0	0.0	0.4	1.42	2.19
96291	BRD-K82846253	U2OS	10 uM	24 h	-0.29	-1.21	0.58	0.0	0.0	0.0
125985	BRD-K82846253	A549	0.04 uM	24 h	-0.23	-0.96	0.09	-0.27	-0.91	0.29
126084	BRD-K82846253	HUVEC	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126130	BRD-K82846253	JURKAT	3.33 uM	24 h	0.0	0.0	0.0	-0.33	-1.1	0.86
126183	BRD-K82846253	MCF10A	0.125 uM	24 h	0.25	1.05	0.17	0.0	0.0	0.0
126239	BRD-K82846253	MDAMB231	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126301	BRD-K82846253	THP1	0.125 uM	24 h	0.0	0.0	0.0	-0.22	-0.75	0.06
126342	BRD-K82846253	YAPC	1.11 uM	24 h	0.24	0.99	0.09	0.0	0.0	0.0
134009	BRD-K82846253	A375	0.08 uM	24 h	-0.29	-1.19	0.53	0.24	0.86	0.16
134067	BRD-K82846253	HA1E	0.74 uM	24 h	0.0	0.0	0.0	-0.28	-0.96	0.42
134104	BRD-K82846253	HEK293	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134150	BRD-K82846253	HELA	0.03 uM	24 h	0.32	1.33	0.84	0.0	0.0	0.0
134182	BRD-K82846253	HT29	0.01 uM	24 h	0.29	1.22	0.48	-0.27	-0.92	0.33

Summary