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CMap Candidate Details

Structure:
CMap ID: C04575
Pert ID: BRD-K95921201
Compound Name: reserpine
Targets: SLC18A1|SLC18A2
MoA: vesicular monoamine transporter inhibitor
SMILES: CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c1cc(OC)c(OC)c(OC)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4263 BRD-K95921201 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4506 BRD-K95921201 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4972 BRD-K95921201 VCAP 10 uM 24 h 0.21 0.89 0.02 0.38 1.36 1.73
37768 BRD-K95921201 ASC 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.79 0.11
37963 BRD-K95921201 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38116 BRD-K95921201 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38231 BRD-K95921201 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.42 -1.4 2.02
38579 BRD-K95921201 NPC 10 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.58
38801 BRD-K95921201 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53378 BRD-K95921201 MCF10A 100 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
128392 BRD-K95921201 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128449 BRD-K95921201 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128559 BRD-K95921201 JURKAT 3.33 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
128651 BRD-K95921201 MDAMB231 0.125 uM 24 h -0.22 -0.9 0.04 0.21 0.76 0.05
128686 BRD-K95921201 PC3 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.01
128731 BRD-K95921201 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128776 BRD-K95921201 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136188 BRD-K95921201 A375 0.25 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.44
136269 BRD-K95921201 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).