CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04589
Pert ID:	BRD-A68281735
Compound Name:	REV-5901
Targets:	ALOX5
MoA:	leukotriene receptor antagonist; lipoxygenase inhibitor
SMILES:	CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2050	BRD-A68281735	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
2648	BRD-A68281735	VCAP	10 uM	6 h	0.0	0.0	0.0	0.27	0.95	0.31
42229	BRD-A68281735	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
42571	BRD-A68281735	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.24	-0.82	0.14
43737	BRD-A68281735	PHH	10 uM	24 h	0.19	0.81	0.0	0.0	0.0	0.0
44023	BRD-A68281735	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95520	BRD-A68281735	A549	10 uM	48 h	0.0	0.0	0.0	0.3	1.05	0.58
95611	BRD-A68281735	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
96306	BRD-A68281735	A375	10 uM	24 h	0.22	0.93	0.05	0.0	0.0	0.0
100290	BRD-A68281735	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
126666	BRD-A68281735	HA1E	0.12 uM	24 h	0.32	1.34	0.89	0.38	1.35	1.72
126761	BRD-A68281735	JURKAT	1.11 uM	24 h	0.22	0.93	0.05	0.31	1.1	0.7
126796	BRD-A68281735	MCF10A	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126871	BRD-A68281735	MDAMB231	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126932	BRD-A68281735	THP1	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134754	BRD-A68281735	HEK293	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134788	BRD-A68281735	HELA	0.01 uM	24 h	0.0	0.0	0.0	-0.2	-0.66	0.01
134816	BRD-A68281735	HT29	0.003 uM	24 h	0.0	0.0	0.0	0.25	0.87	0.18
134847	BRD-A68281735	HUVEC	0.01 uM	24 h	-0.22	-0.91	0.05	0.31	1.09	0.67
134955	BRD-A68281735	PC3	0.001 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134985	BRD-A68281735	YAPC	0.001 uM	24 h	0.24	1.01	0.11	0.19	0.67	0.01

Summary