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CMap Candidate Details

Structure:
CMap ID: C04619
Pert ID: BRD-K55187425
Compound Name: rigosertib
Targets: PLK1
MoA: cell cycle inhibitor; PLK inhibitor
SMILES: COc1cc(OC)c(\C=C\S(=O)(=O)Cc2ccc(OC)c(NCC(O)=O)c2)c(OC)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90816 BRD-K55187425 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91814 BRD-K55187425 HS578T 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91896 BRD-K55187425 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91941 BRD-K55187425 SKBR3 0.37 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
94416 BRD-K55187425 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94449 BRD-K55187425 A549 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.71
94484 BRD-K55187425 ASC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94553 BRD-K55187425 CD34 10 uM 24 h 0.29 1.21 0.47 0.0 0.0 0.0
94600 BRD-K55187425 HCC515 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94644 BRD-K55187425 HEK293 3.33 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.81
94694 BRD-K55187425 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94748 BRD-K55187425 HME1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94794 BRD-K55187425 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94840 BRD-K55187425 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.65
94893 BRD-K55187425 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94977 BRD-K55187425 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95019 BRD-K55187425 NEU 1.11 uM 24 h 0.25 1.03 0.14 -0.3 -1.02 0.59
95078 BRD-K55187425 NPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95119 BRD-K55187425 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95166 BRD-K55187425 SHSY5Y 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95236 BRD-K55187425 SKL 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95276 BRD-K55187425 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).