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CMap Candidate Details

Structure:
CMap ID: C04624
Pert ID: BRD-K70490179
Compound Name: rimcazole
Targets: SIGMAR1
MoA: sigma receptor antagonist
SMILES: C[C@H]1CN(CCCn2c3ccccc3c3ccccc23)C[C@@H](C)N1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
22831 BRD-K70490179 HCC515 10 uM 6 h 0.0 0.0 0.0 0.35 1.24 1.24
23129 BRD-K70490179 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.36 1.28 1.4
24340 BRD-K70490179 VCAP 10 uM 6 h -0.26 -1.1 0.34 0.0 0.0 0.0
126630 BRD-K70490179 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126653 BRD-K70490179 A549 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 1.01
126676 BRD-K70490179 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126694 BRD-K70490179 HEK293 10 uM 24 h -0.23 -0.94 0.08 0.3 1.07 0.62
126719 BRD-K70490179 HELA 10 uM 24 h 0.23 0.97 0.08 0.33 1.15 0.89
126744 BRD-K70490179 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126781 BRD-K70490179 JURKAT 10 uM 24 h 0.24 1.02 0.12 0.0 0.0 0.0
126804 BRD-K70490179 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126842 BRD-K70490179 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126887 BRD-K70490179 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126915 BRD-K70490179 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126954 BRD-K70490179 THP1 10 uM 24 h -0.28 -1.16 0.47 0.0 0.0 0.0
126996 BRD-K70490179 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134868 BRD-K70490179 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).