CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04627
Pert ID:	BRD-K84783599
Compound Name:	riociguat
Targets:	GUCY1A2\|GUCY1A3\|GUCY1B2\|GUCY1B3
MoA:	guanylate cyclase stimulant
SMILES:	COC(=O)N(C)c1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
126013	BRD-K84783599	HA1E	0.125 uM	24 h	0.0	0.0	0.0	-0.24	-0.79	0.11
126095	BRD-K84783599	HUVEC	0.37 uM	24 h	0.0	0.0	0.0	-0.31	-1.06	0.72
126143	BRD-K84783599	JURKAT	1.11 uM	24 h	0.0	0.0	0.0	-0.38	-1.28	1.45
126196	BRD-K84783599	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126314	BRD-K84783599	THP1	3.33 uM	24 h	-0.19	-0.8	0.0	0.0	0.0	0.0
126345	BRD-K84783599	YAPC	1.11 uM	24 h	-0.24	-0.99	0.13	-0.26	-0.88	0.26
134018	BRD-K84783599	A375	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134046	BRD-K84783599	A549	0.25 uM	24 h	-0.22	-0.93	0.07	-0.25	-0.85	0.19
134117	BRD-K84783599	HEK293	2.22 uM	24 h	0.25	1.04	0.14	0.34	1.2	1.12
134160	BRD-K84783599	HELA	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134190	BRD-K84783599	HT29	0.03 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.59
134237	BRD-K84783599	MCF??7.00	0.25 uM	24 h	0.28	1.17	0.36	0.0	0.0	0.0
134271	BRD-K84783599	MDAMB231	0.25 uM	24 h	0.0	0.0	0.0	0.27	0.95	0.31
134294	BRD-K84783599	PC3	0.74 uM	24 h	0.18	0.73	0.0	-0.34	-1.15	1.08

Summary