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CMap Candidate Details

Structure:
CMap ID: C04660
Pert ID: BRD-K64538373
Compound Name: Ro-4987655
Targets: MAP2K1
MoA: MEK inhibitor
SMILES: OCCONC(=O)c1cc(CN2OCCCC2=O)c(F)c(F)c1Nc1ccc(I)cc1F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124597 BRD-K64538373 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124693 BRD-K64538373 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124798 BRD-K64538373 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.12
124839 BRD-K64538373 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132662 BRD-K64538373 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132721 BRD-K64538373 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.38 1.34 1.72
132755 BRD-K64538373 HEK293 2.22 uM 24 h -0.25 -1.04 0.22 0.0 0.0 0.0
132790 BRD-K64538373 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.38 1.35 1.72
132834 BRD-K64538373 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.38
132870 BRD-K64538373 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132899 BRD-K64538373 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132931 BRD-K64538373 THP1 0.08 uM 24 h -0.29 -1.22 0.62 -0.27 -0.91 0.31
132952 BRD-K64538373 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.6
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).