CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04672
Pert ID:	BRD-A34255068
Compound Name:	rolipram
Targets:
MoA:	phosphodiesterase inhibitor
SMILES:	COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1423	BRD-A34255068	NPC	1.25 uM	24 h	0.18	0.77	0.0	0.0	0.0	0.0
5721	BRD-A34255068	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
9588	BRD-A34255068	H1299	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
10664	BRD-A34255068	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.3	-1.01	0.58
11336	BRD-A34255068	NCIH2073	10 uM	6 h	0.0	0.0	0.0	0.27	0.97	0.35
11905	BRD-A34255068	NCIH596	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
12202	BRD-A34255068	NOMO1	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
25471	BRD-A34255068	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
46195	BRD-A34255068	PHH	10 uM	24 h	0.0	0.0	0.0	0.3	1.05	0.57
46511	BRD-A34255068	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91379	BRD-A34255068	HUH7	12 uM	72 h	0.28	1.15	0.32	0.0	0.0	0.0
95831	BRD-A34255068	A549	1.11 uM	6 h	0.19	0.78	0.0	0.0	0.0	0.0
95891	BRD-A34255068	YAPC	1.11 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
121911	BRD-A34255068	A375	10 uM	24 h	0.0	0.0	0.0	-0.37	-1.25	1.35
121972	BRD-A34255068	HEK293	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122026	BRD-A34255068	HT29	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122078	BRD-A34255068	HUVEC	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122096	BRD-A34255068	MCF10A	1.11 uM	24 h	0.31	1.3	0.73	-0.37	-1.24	1.35
122125	BRD-A34255068	MCF??7.00	0.04 uM	24 h	0.0	0.0	0.0	-0.36	-1.22	1.25
130246	BRD-A34255068	HA1E	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130306	BRD-A34255068	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130466	BRD-A34255068	MDAMB231	2.22 uM	24 h	0.27	1.13	0.3	0.0	0.0	0.0
130486	BRD-A34255068	PC3	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130509	BRD-A34255068	THP1	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary