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CMap Candidate Details

Structure:
CMap ID: C04690
Pert ID: BRD-K82941592
Compound Name: rosuvastatin
Targets: HMGCR
MoA: HMGCR inhibitor
SMILES: CC(C)c1nc(nc(-c2ccc(F)cc2)c1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)N(C)S(C)(=O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5690 BRD-K82941592 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5960 BRD-K82941592 HEPG2 10 uM 6 h 0.16 0.67 0.0 0.26 0.93 0.27
6595 BRD-K82941592 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37749 BRD-K82941592 ASC 10 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.88
38564 BRD-K82941592 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38784 BRD-K82941592 PHH 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
39014 BRD-K82941592 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95515 BRD-K82941592 A549 1.11 uM 48 h 0.0 0.0 0.0 -0.27 -0.91 0.31
95634 BRD-K82941592 U2OS 10 uM 24 h -0.33 -1.39 1.09 0.26 0.93 0.26
125965 BRD-K82941592 A375 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
126006 BRD-K82941592 HA1E 10 uM 24 h -0.22 -0.91 0.06 -0.31 -1.05 0.72
126085 BRD-K82941592 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
126131 BRD-K82941592 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126184 BRD-K82941592 MCF10A 3.33 uM 24 h 0.25 1.04 0.15 0.26 0.94 0.28
126240 BRD-K82941592 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126266 BRD-K82941592 PC3 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.53
126302 BRD-K82941592 THP1 0.37 uM 24 h 0.17 0.73 0.0 0.0 0.0 0.0
134105 BRD-K82941592 HEK293 0.25 uM 24 h 0.22 0.93 0.05 0.37 1.31 1.59
134151 BRD-K82941592 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134183 BRD-K82941592 HT29 0.25 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
134229 BRD-K82941592 MCF??7.00 0.74 uM 24 h 0.32 1.33 0.85 0.0 0.0 0.0
134314 BRD-K82941592 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).