CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04727
Pert ID:	BRD-K98004573
Compound Name:	rupatadine
Targets:	HRH1\|PTAFR
MoA:	histamine receptor antagonist; platelet activating factor receptor antagonist
SMILES:	Cc1cncc(CN2CCC(CC2)=C2c3ccc(Cl)cc3CCc3cccnc23)c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
128123	BRD-K98004573	A375	10 uM	24 h	0.28	1.18	0.39	0.0	0.0	0.0
128154	BRD-K98004573	A549	0.125 uM	24 h	0.0	0.0	0.0	0.4	1.42	2.2
128194	BRD-K98004573	HT29	10 uM	24 h	0.25	1.04	0.15	0.0	0.0	0.0
128247	BRD-K98004573	MCF10A	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128274	BRD-K98004573	MCF??7.00	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128326	BRD-K98004573	MDAMB231	3.33 uM	24 h	0.32	1.35	0.93	-0.24	-0.82	0.15
128342	BRD-K98004573	PC3	10 uM	24 h	0.0	0.0	0.0	0.32	1.12	0.77
128366	BRD-K98004573	THP1	10 uM	24 h	0.25	1.05	0.17	-0.27	-0.91	0.31
135831	BRD-K98004573	HA1E	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135869	BRD-K98004573	HEK293	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135921	BRD-K98004573	HELA	0.01 uM	24 h	0.0	0.0	0.0	-0.28	-0.94	0.38
136011	BRD-K98004573	JURKAT	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136157	BRD-K98004573	YAPC	0.25 uM	24 h	0.0	0.0	0.0	0.29	1.03	0.52

Summary