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CMap Candidate Details

Structure:
CMap ID: C04729
Pert ID: BRD-K20482099
Compound Name: rutin
Targets: AKR1C3
MoA: antioxidant; capillary stabilizing agent; nitric oxide scavenger
SMILES: C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(oc4cc(O)cc(O)c4c3=O)-c3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5592 BRD-K20482099 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6265 BRD-K20482099 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6400 BRD-K20482099 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
24656 BRD-K20482099 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24757 BRD-K20482099 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24880 BRD-K20482099 HT29 10 uM 6 h 0.0 0.0 0.0 0.26 0.93 0.28
25009 BRD-K20482099 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44337 BRD-K20482099 A375 10 uM 6 h -0.23 -0.96 0.1 0.0 0.0 0.0
44895 BRD-K20482099 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45198 BRD-K20482099 HEPG2 10 uM 6 h 0.25 1.03 0.13 0.33 1.15 0.9
46013 BRD-K20482099 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46331 BRD-K20482099 PHH 10 uM 24 h 0.29 1.21 0.47 0.29 1.04 0.56
46647 BRD-K20482099 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).