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CMap Candidate Details

Structure:
CMap ID: C04730
Pert ID: BRD-K53972329
Compound Name: ruxolitinib
Targets: JAK1|JAK2|JAK3|TYK2
MoA: JAK inhibitor
SMILES: N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
86 BRD-K53972329 HBL1 10 uM 24 h -0.17 -0.71 0.0 0.0 0.0 0.0
123 BRD-K53972329 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
255 BRD-K53972329 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
350 BRD-K53972329 OCILY3 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
372 BRD-K53972329 SKMEL5 10 uM 24 h -0.2 -0.85 0.01 -0.28 -0.95 0.42
404 BRD-K53972329 THP1 10 uM 24 h -0.24 -1.0 0.14 -0.22 -0.74 0.06
33562 BRD-K53972329 A375 10 uM 6 h 0.33 1.38 0.97 0.0 0.0 0.0
33914 BRD-K53972329 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34126 BRD-K53972329 ASC 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.15
34909 BRD-K53972329 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.29 1.5
35162 BRD-K53972329 HT29 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.99 0.5
35583 BRD-K53972329 NEU 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
36090 BRD-K53972329 PC3 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.77 0.08
36285 BRD-K53972329 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36587 BRD-K53972329 SKB 10 uM 24 h -0.27 -1.13 0.41 -0.37 -1.24 1.3
36977 BRD-K53972329 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87325 BRD-K53972329 BJAB 10 uM 6 h 0.18 0.76 0.0 -0.28 -0.93 0.34
87452 BRD-K53972329 KMS34 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
87485 BRD-K53972329 MINO 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.64
87556 BRD-K53972329 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87657 BRD-K53972329 OCILY19 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
87868 BRD-K53972329 TMD8 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90589 BRD-K53972329 HCT116 3.33 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.11
90678 BRD-K53972329 MCF10A 0.04 uM 24 h 0.34 1.41 1.03 0.0 0.0 0.0
92033 BRD-K53972329 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92116 BRD-K53972329 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.06
92171 BRD-K53972329 HS578T 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92299 BRD-K53972329 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92379 BRD-K53972329 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.18
95809 BRD-K53972329 NPC 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95921 BRD-K53972329 YAPC 0.5 uM 6 h -0.25 -1.06 0.24 0.3 1.05 0.57
97974 BRD-K53972329 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.93
98010 BRD-K53972329 MCF??7.00 10 uM 24 h 0.26 1.07 0.2 -0.35 -1.16 1.11
98045 BRD-K53972329 P1A82 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).