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CMap Candidate Details

Structure:
CMap ID: C04782
Pert ID: BRD-K19540840
Compound Name: saracatinib
Targets: ABL1|LCK|SRC|YES1
MoA: src inhibitor
SMILES: CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c5OCOc5ccc4Cl)ncnc3c2)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
30390 BRD-K19540840 ASC 10 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.82
32149 BRD-K19540840 NEU 10 uM 24 h 0.22 0.93 0.05 -0.28 -0.96 0.42
32973 BRD-K19540840 SKB 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.97
35745 BRD-K19540840 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36218 BRD-K19540840 PHH 10 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
83031 BRD-K19540840 HEPG2 10 uM 24 h -0.28 -1.17 0.49 -0.31 -1.04 0.68
87329 BRD-K19540840 BJAB 10 uM 6 h 0.24 1.01 0.12 0.0 0.0 0.0
87370 BRD-K19540840 HBL1 0.66 uM 24 h -0.21 -0.89 0.03 0.0 0.0 0.0
87420 BRD-K19540840 K562 10 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.45
87467 BRD-K19540840 KMS34 10 uM 24 h -0.26 -1.1 0.35 0.0 0.0 0.0
87528 BRD-K19540840 MINO 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87572 BRD-K19540840 NALM6 10 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
87622 BRD-K19540840 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
87672 BRD-K19540840 OCILY19 0.125 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
87723 BRD-K19540840 OCILY3 2.5 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
87771 BRD-K19540840 SKMEL5 10 uM 24 h -0.25 -1.04 0.22 0.0 0.0 0.0
87823 BRD-K19540840 THP1 10 uM 6 h -0.22 -0.91 0.05 -0.32 -1.07 0.75
87872 BRD-K19540840 TMD8 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90393 BRD-K19540840 VCAP 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91734 BRD-K19540840 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92403 BRD-K19540840 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92456 BRD-K19540840 BT20 10 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.66
92523 BRD-K19540840 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92603 BRD-K19540840 HS578T 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92656 BRD-K19540840 LNCAP 10 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.6
92724 BRD-K19540840 MCF10A 0.12 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92767 BRD-K19540840 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97319 BRD-K19540840 HAP1 3.33 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
118107 BRD-K19540840 A549 10 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.37
118196 BRD-K19540840 HCC515 10 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.85
118328 BRD-K19540840 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120915 BRD-K19540840 HA1E 0.125 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.21
120964 BRD-K19540840 HEK293 0.04 uM 24 h -0.24 -1.01 0.16 0.0 0.0 0.0
121121 BRD-K19540840 YAPC 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.13
129169 BRD-K19540840 HELA 0.25 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
129198 BRD-K19540840 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.35 1.23 1.19
129224 BRD-K19540840 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).