CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04802
Pert ID:	BRD-K30867024
Compound Name:	SB-216641
Targets:	HTR1A\|HTR1B\|HTR1D\|HTR2A\|HTR2B\|HTR2C
MoA:	serotonin receptor antagonist
SMILES:	COc1ccc(NC(=O)c2ccc(cc2)-c2ccc(cc2C)-c2noc(C)n2)cc1OCCN(C)C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
6177	BRD-K30867024	PC3	10 uM	24 h	0.0	0.0	0.0	0.4	1.4	2.18
6308	BRD-K30867024	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39112	BRD-K30867024	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
39663	BRD-K30867024	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40783	BRD-K30867024	NEU	10 uM	24 h	0.23	0.98	0.09	-0.28	-0.93	0.34
41084	BRD-K30867024	NPC	10 uM	24 h	0.21	0.89	0.02	0.0	0.0	0.0
41417	BRD-K30867024	SKB	10 uM	24 h	0.0	0.0	0.0	-0.38	-1.29	1.53
82759	BRD-K30867024	A549	4 uM	24 h	-0.18	-0.76	0.0	0.0	0.0	0.0
82850	BRD-K30867024	HA1E	4 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
82943	BRD-K30867024	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
83040	BRD-K30867024	HEPG2	4 uM	24 h	-0.2	-0.84	0.01	0.0	0.0	0.0
83137	BRD-K30867024	HT29	10 uM	24 h	0.19	0.81	0.0	0.23	0.83	0.11
83223	BRD-K30867024	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99820	BRD-K30867024	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary