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CMap Candidate Details

Structure:
CMap ID: C00489
Pert ID: BRD-K96615647
Compound Name: AV-608
Targets: TACR1
MoA: tachykinin antagonist
SMILES: FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CC[C@@H](C[C@H]1Cc1ccc(Cl)cc1)NC(=O)c1ccnc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128107 BRD-K96615647 A375 10 uM 24 h 0.35 1.48 1.12 0.0 0.0 0.0
128137 BRD-K96615647 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128167 BRD-K96615647 HEK293 3.33 uM 24 h -0.25 -1.05 0.24 -0.27 -0.92 0.32
128218 BRD-K96615647 MCF10A 0.04 uM 24 h -0.23 -0.95 0.09 0.28 0.99 0.4
128258 BRD-K96615647 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128297 BRD-K96615647 MDAMB231 0.04 uM 24 h 0.27 1.12 0.26 0.0 0.0 0.0
128351 BRD-K96615647 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135807 BRD-K96615647 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135892 BRD-K96615647 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135938 BRD-K96615647 HT29 0.25 uM 24 h 0.27 1.12 0.27 -0.26 -0.88 0.26
135981 BRD-K96615647 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136056 BRD-K96615647 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136127 BRD-K96615647 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).