CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04921
Pert ID:	BRD-K80700417
Compound Name:	SGI-1776
Targets:	FLT3\|PIM1\|PIM2\|PIM3
MoA:	Pim kinase inhibitor
SMILES:	CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
92953	BRD-K80700417	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92979	BRD-K80700417	CD34	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93032	BRD-K80700417	HA1E	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93070	BRD-K80700417	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93117	BRD-K80700417	HELA	10 uM	24 h	0.2	0.84	0.0	0.0	0.0	0.0
93156	BRD-K80700417	HEPG2	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.68
93205	BRD-K80700417	HUVEC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93262	BRD-K80700417	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93305	BRD-K80700417	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93387	BRD-K80700417	NPC	3.33 uM	24 h	0.0	0.0	0.0	-0.3	-1.03	0.62
93438	BRD-K80700417	PC3	0.12 uM	24 h	0.0	0.0	0.0	-0.33	-1.1	0.87
93506	BRD-K80700417	SKL	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93533	BRD-K80700417	THP1	3.33 uM	24 h	-0.24	-0.99	0.13	0.0	0.0	0.0
117009	BRD-K80700417	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
117125	BRD-K80700417	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
117220	BRD-K80700417	HT29	10 uM	24 h	0.19	0.79	0.0	-0.25	-0.83	0.16
117259	BRD-K80700417	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126388	BRD-K80700417	A549	10 uM	24 h	-0.22	-0.92	0.06	0.0	0.0	0.0
126560	BRD-K80700417	MDAMB231	10 uM	24 h	-0.19	-0.8	0.0	0.24	0.84	0.12
126616	BRD-K80700417	YAPC	10 uM	24 h	0.0	0.0	0.0	0.34	1.19	1.03

Summary