Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C04931
Pert ID: BRD-A62071884
Compound Name: siguazodan
Targets: PDE3A
MoA: phosphodiesterase inhibitor
SMILES: CN\C(NC#N)=N/c1ccc(cc1)C1=NNC(=O)CC1C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2812 BRD-A62071884 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3111 BRD-A62071884 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3695 BRD-A62071884 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.11
42223 BRD-A62071884 ASC 10 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
42565 BRD-A62071884 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43424 BRD-A62071884 NPC 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
43732 BRD-A62071884 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44019 BRD-A62071884 SKB 10 uM 24 h 0.19 0.77 0.0 0.22 0.78 0.07
91381 BRD-A62071884 HUH7 12 uM 72 h 0.26 1.07 0.19 0.0 0.0 0.0
124954 BRD-A62071884 A549 0.37 uM 24 h -0.25 -1.04 0.21 0.0 0.0 0.0
125016 BRD-A62071884 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125067 BRD-A62071884 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.29
125100 BRD-A62071884 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.3
125145 BRD-A62071884 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132972 BRD-A62071884 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133031 BRD-A62071884 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133108 BRD-A62071884 HT29 2.22 uM 24 h 0.31 1.31 0.76 0.32 1.13 0.8
133138 BRD-A62071884 JURKAT 0.74 uM 24 h -0.32 -1.32 0.83 0.0 0.0 0.0
133215 BRD-A62071884 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133280 BRD-A62071884 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
133309 BRD-A62071884 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).