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CMap Candidate Details

Structure:
CMap ID: C04944
Pert ID: BRD-K84937637
Compound Name: sirolimus
Targets: FGF2|FKBP1A|MTOR
MoA: mTOR inhibitor
SMILES: CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1446 BRD-K84937637 NPC 0.3 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34196 BRD-K84937637 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35630 BRD-K84937637 NEU 10 uM 24 h -0.24 -0.99 0.13 -0.3 -1.01 0.58
36370 BRD-K84937637 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36668 BRD-K84937637 SKB 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.58
36884 BRD-K84937637 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90918 BRD-K84937637 HUH7 3.33 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
119190 BRD-K84937637 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119246 BRD-K84937637 HA1E 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119278 BRD-K84937637 HCC515 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119305 BRD-K84937637 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119332 BRD-K84937637 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
119356 BRD-K84937637 MCF??7.00 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119886 BRD-K84937637 A549 10 uM 6 h -0.27 -1.11 0.37 -0.35 -1.17 1.12
119925 BRD-K84937637 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).