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CMap Candidate Details

Structure:
CMap ID: C04967
Pert ID: BRD-K20755323
Compound Name: SKI-II
Targets: SPHK1
MoA: sphingosine kinase inhibitor
SMILES: Oc1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9384 BRD-K20755323 AGS 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9696 BRD-K20755323 H1299 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10045 BRD-K20755323 HA1E 40 uM 6 h -0.23 -0.97 0.1 0.24 0.86 0.15
10121 BRD-K20755323 HCC515 40 uM 24 h 0.0 0.0 0.0 0.23 0.8 0.08
10480 BRD-K20755323 HCT116 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10961 BRD-K20755323 HT29 40 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.4
11445 BRD-K20755323 NCIH2073 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11734 BRD-K20755323 NCIH508 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12010 BRD-K20755323 NCIH596 40 uM 6 h -0.29 -1.22 0.62 0.0 0.0 0.0
12286 BRD-K20755323 NOMO1 40 uM 6 h 0.0 0.0 0.0 -0.26 -0.87 0.24
12435 BRD-K20755323 PC3 40 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12757 BRD-K20755323 SW480 40 uM 6 h 0.0 0.0 0.0 -0.22 -0.74 0.06
13237 BRD-K20755323 U937 40 uM 6 h -0.27 -1.14 0.42 0.28 0.98 0.36
13599 BRD-K20755323 VCAP 40 uM 6 h 0.0 0.0 0.0 -0.36 -1.21 1.22
44549 BRD-K20755323 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44898 BRD-K20755323 ASC 10 uM 24 h -0.28 -1.16 0.45 0.0 0.0 0.0
45200 BRD-K20755323 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46333 BRD-K20755323 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46650 BRD-K20755323 SKB 10 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.25
90562 BRD-K20755323 MCF??7.00 10 uM 6 h 0.27 1.13 0.28 0.0 0.0 0.0
96731 BRD-K20755323 A375 1.11 uM 24 h -0.15 -0.64 0.0 0.0 0.0 0.0
97442 BRD-K20755323 NKDBA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99739 BRD-K20755323 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).