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CMap Candidate Details

Structure:
CMap ID: C00497
Pert ID: BRD-K62196610
Compound Name: AVN-944
Targets: IMPDH1|IMPDH2
MoA: inosine monophosphate dehydrogenase inhibitor
SMILES: CC[C@H](CC#N)OC(=O)N[C@@H](C)c1cccc(NC(=O)Nc2ccc(-c3cnco3)c(OC)c2)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124952 BRD-K62196610 A549 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
124990 BRD-K62196610 HA1E 10 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
125014 BRD-K62196610 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125045 BRD-K62196610 HT29 1.11 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
125065 BRD-K62196610 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125091 BRD-K62196610 MCF??7.00 10 uM 24 h 0.25 1.03 0.14 0.33 1.15 0.9
125143 BRD-K62196610 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125194 BRD-K62196610 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132971 BRD-K62196610 A375 0.74 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
133029 BRD-K62196610 HEK293 0.74 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.87
133137 BRD-K62196610 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133251 BRD-K62196610 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133278 BRD-K62196610 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).