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CMap Candidate Details

Structure:
CMap ID: C04984
Pert ID: BRD-K71512533
Compound Name: SNS-314
Targets: AURKA|AURKB|AURKC
MoA: Aurora kinase inhibitor
SMILES: Clc1cccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29931 BRD-K71512533 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30104 BRD-K71512533 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30536 BRD-K71512533 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30828 BRD-K71512533 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31119 BRD-K71512533 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31432 BRD-K71512533 HEPG2 10 uM 6 h -0.28 -1.18 0.51 0.0 0.0 0.0
31533 BRD-K71512533 HT29 10 uM 6 h 0.0 0.0 0.0 0.4 1.42 2.2
32066 BRD-K71512533 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32226 BRD-K71512533 NEU 10 uM 24 h -0.29 -1.2 0.57 0.0 0.0 0.0
32511 BRD-K71512533 NPC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
32820 BRD-K71512533 PC3 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.72 0.04
33119 BRD-K71512533 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33499 BRD-K71512533 VCAP 10 uM 6 h 0.0 0.0 0.0 0.35 1.23 1.24
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).