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CMap Candidate Details

Structure:
CMap ID: C04985
Pert ID: BRD-K71281111
Compound Name: SNX-2112
Targets:
MoA: HSP inhibitor
SMILES: CC1(C)Cc2c(c(nn2-c2ccc(C(N)=O)c(N[C@H]3CC[C@H](O)CC3)c2)C(F)(F)F)C(=O)C1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
115659 BRD-K71281111 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115774 BRD-K71281111 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
115822 BRD-K71281111 HEPG2 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126437 BRD-K71281111 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126494 BRD-K71281111 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126577 BRD-K71281111 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126603 BRD-K71281111 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134375 BRD-K71281111 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134399 BRD-K71281111 HA1E 2.22 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
134427 BRD-K71281111 HELA 0.25 uM 24 h -0.24 -0.99 0.14 -0.28 -0.95 0.4
134503 BRD-K71281111 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 -0.21 -0.72 0.04
134539 BRD-K71281111 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134567 BRD-K71281111 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
134598 BRD-K71281111 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).