CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04987
Pert ID:	BRD-K85406984
Compound Name:	sobetirome
Targets:	THRA\|THRB
MoA:	thyroid hormone receptor agonist
SMILES:	CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)ccc1O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
126017	BRD-K85406984	HA1E	0.37 uM	24 h	0.0	0.0	0.0	-0.37	-1.26	1.35
126100	BRD-K85406984	HUVEC	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126151	BRD-K85406984	JURKAT	0.37 uM	24 h	0.0	0.0	0.0	-0.34	-1.15	1.05
126202	BRD-K85406984	MCF10A	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126224	BRD-K85406984	MCF??7.00	3.33 uM	24 h	0.2	0.86	0.01	0.0	0.0	0.0
126246	BRD-K85406984	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0	-0.34	-1.14	1.01
126273	BRD-K85406984	PC3	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126321	BRD-K85406984	THP1	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134022	BRD-K85406984	A375	0.01 uM	24 h	-0.32	-1.31	0.82	0.0	0.0	0.0
134051	BRD-K85406984	A549	0.01 uM	24 h	0.33	1.36	0.97	0.0	0.0	0.0
134125	BRD-K85406984	HEK293	0.01 uM	24 h	0.32	1.33	0.85	-0.27	-0.92	0.32
134166	BRD-K85406984	HELA	0.03 uM	24 h	-0.23	-0.96	0.09	0.0	0.0	0.0
134194	BRD-K85406984	HT29	2.22 uM	24 h	0.0	0.0	0.0	-0.33	-1.11	0.91
134329	BRD-K85406984	YAPC	0.03 uM	24 h	-0.23	-0.96	0.09	0.0	0.0	0.0

Summary