CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00500
Pert ID:	BRD-K29905972
Compound Name:	axitinib
Targets:	CSF1\|FLT1\|FLT4\|KDR\|PLK4
MoA:	PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor
SMILES:	CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1190	BRD-K29905972	PC3	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.11	0.9
1221	BRD-K29905972	A549	10 uM	24 h	-0.21	-0.85	0.01	0.27	0.96	0.34
1302	BRD-K29905972	MCF??7.00	10 uM	6 h	0.22	0.93	0.04	0.31	1.09	0.67
30413	BRD-K29905972	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
32398	BRD-K29905972	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
32996	BRD-K29905972	SKB	10 uM	24 h	0.26	1.09	0.23	0.35	1.23	1.23
33453	BRD-K29905972	VCAP	10 uM	6 h	0.0	0.0	0.0	0.24	0.86	0.16
95675	BRD-K29905972	U2OS	10 uM	48 h	-0.17	-0.72	0.0	0.0	0.0	0.0
118051	BRD-K29905972	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
118138	BRD-K29905972	HA1E	10 uM	24 h	0.28	1.16	0.36	0.0	0.0	0.0
118184	BRD-K29905972	HCC515	3.33 uM	24 h	-0.25	-1.05	0.23	0.0	0.0	0.0
118233	BRD-K29905972	HEPG2	3.33 uM	24 h	-0.22	-0.9	0.04	-0.31	-1.05	0.7
118277	BRD-K29905972	HT29	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary