CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05014
Pert ID:	BRD-K19796430
Compound Name:	sonidegib
Targets:	SMO
MoA:	smoothened receptor antagonist
SMILES:	C[C@H]1CN(C[C@@H](C)O1)c1ccc(NC(=O)c2cccc(-c3ccc(OC(F)(F)F)cc3)c2C)cn1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
8923	BRD-K19796430	A375	10 uM	24 h	0.0	0.0	0.0	-0.23	-0.78	0.09
9381	BRD-K19796430	AGS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
9692	BRD-K19796430	H1299	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
10111	BRD-K19796430	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
11441	BRD-K19796430	NCIH2073	10 uM	6 h	0.19	0.81	0.0	0.47	1.66	2.46
12007	BRD-K19796430	NCIH596	10 uM	6 h	0.0	0.0	0.0	-0.27	-0.92	0.32
12283	BRD-K19796430	NOMO1	10 uM	6 h	0.0	0.0	0.0	0.3	1.06	0.59
12753	BRD-K19796430	SW480	10 uM	6 h	0.0	0.0	0.0	-0.32	-1.07	0.76
90394	BRD-K19796430	VCAP	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95491	BRD-K19796430	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95606	BRD-K19796430	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
95712	BRD-K19796430	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
95973	BRD-K19796430	PHH	10 uM	24 h	0.0	0.0	0.0	0.37	1.3	1.57
118246	BRD-K19796430	HEPG2	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
118370	BRD-K19796430	PC3	10 uM	24 h	-0.25	-1.05	0.24	0.26	0.91	0.24
118754	BRD-K19796430	HA1E	0.12 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.45
118878	BRD-K19796430	HT29	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary