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CMap Candidate Details

Structure:
CMap ID: C00505
Pert ID: BRD-K05804044
Compound Name: AZ-628
Targets: BRAF|RAF1
MoA: RAF inhibitor
SMILES: Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1Nc1ccc2ncn(C)c(=O)c2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
65 BRD-K05804044 BJAB 10 uM 4 h 0.0 0.0 0.0 0.24 0.83 0.12
98 BRD-K05804044 HBL1 2.5 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
132 BRD-K05804044 K562 0.66 uM 24 h 0.0 0.0 0.0 0.4 1.41 2.18
189 BRD-K05804044 KMS34 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
229 BRD-K05804044 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
268 BRD-K05804044 OCILY10 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
292 BRD-K05804044 OCILY19 10 uM 24 h 0.16 0.66 0.0 -0.29 -0.98 0.47
343 BRD-K05804044 OCILY3 10 uM 24 h 0.22 0.92 0.04 0.19 0.67 0.01
387 BRD-K05804044 SKMEL5 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
428 BRD-K05804044 THP1 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
468 BRD-K05804044 TMD8 2.5 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
1330 BRD-K05804044 U2OS 10 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
33553 BRD-K05804044 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33888 BRD-K05804044 A549 10 uM 6 h -0.27 -1.12 0.38 0.0 0.0 0.0
34546 BRD-K05804044 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35291 BRD-K05804044 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35718 BRD-K05804044 NPC 10 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
36190 BRD-K05804044 PHH 10 uM 24 h 0.0 0.0 0.0 0.22 0.76 0.05
36483 BRD-K05804044 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36943 BRD-K05804044 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91531 BRD-K05804044 BT20 10 uM 6 h 0.26 1.1 0.24 0.0 0.0 0.0
91570 BRD-K05804044 HS578T 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
91744 BRD-K05804044 SKBR3 10 uM 24 h 0.27 1.14 0.3 0.0 0.0 0.0
92923 BRD-K05804044 ASC 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.36
92985 BRD-K05804044 CD34 10 uM 24 h 0.0 0.0 0.0 0.23 0.8 0.08
93162 BRD-K05804044 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93211 BRD-K05804044 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.28
93268 BRD-K05804044 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93309 BRD-K05804044 MCF10A 1.11 uM 24 h 0.25 1.06 0.18 0.33 1.18 1.01
93476 BRD-K05804044 SKL 10 uM 24 h 0.0 0.0 0.0 0.44 1.54 2.31
122598 BRD-K05804044 HA1E 10 uM 24 h -0.21 -0.86 0.02 -0.2 -0.68 0.02
122630 BRD-K05804044 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122656 BRD-K05804044 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122678 BRD-K05804044 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122790 BRD-K05804044 PC3 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.69
131114 BRD-K05804044 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.37 1.32 1.71
131179 BRD-K05804044 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).