CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05144
Pert ID:	BRD-K50938287
Compound Name:	sumatriptan
Targets:	HTR1A\|HTR1B\|HTR1D\|HTR1E\|HTR1F\|HTR5A\|HTR6\|HTR7
MoA:	serotonin receptor agonist
SMILES:	CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
25517	BRD-K50938287	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.29	-0.97	0.45
91324	BRD-K50938287	HUH7	8 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
124774	BRD-K50938287	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.53
124822	BRD-K50938287	PC3	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124865	BRD-K50938287	THP1	0.125 uM	24 h	0.0	0.0	0.0	-0.41	-1.37	2.02
132654	BRD-K50938287	A375	0.01 uM	24 h	0.25	1.04	0.16	-0.28	-0.93	0.35
132677	BRD-K50938287	A549	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132710	BRD-K50938287	HA1E	0.74 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.25
132735	BRD-K50938287	HEK293	0.01 uM	24 h	-0.25	-1.06	0.24	0.0	0.0	0.0
132778	BRD-K50938287	HELA	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132803	BRD-K50938287	HT29	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132821	BRD-K50938287	JURKAT	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132852	BRD-K50938287	MCF10A	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132892	BRD-K50938287	MCF??7.00	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132939	BRD-K50938287	YAPC	0.01 uM	24 h	0.22	0.93	0.05	0.0	0.0	0.0

Summary