CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05179
Pert ID:	BRD-K69608737
Compound Name:	tacrolimus
Targets:	FKBP1A
MoA:	calcineurin inhibitor
SMILES:	CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
6367	BRD-K69608737	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37721	BRD-K69608737	ASC	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.03	0.62
38993	BRD-K69608737	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95812	BRD-K69608737	NPC	10 uM	6 h	0.0	0.0	0.0	-0.28	-0.93	0.34
95930	BRD-K69608737	YAPC	10 uM	6 h	0.0	0.0	0.0	0.35	1.25	1.29
115975	BRD-K69608737	A375	10 uM	24 h	0.0	0.0	0.0	-0.25	-0.83	0.16
116016	BRD-K69608737	A549	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.99	0.5
116055	BRD-K69608737	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
116097	BRD-K69608737	HCC515	0.125 uM	24 h	0.34	1.4	1.02	0.2	0.7	0.02
116143	BRD-K69608737	HEPG2	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
116188	BRD-K69608737	HT29	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.46
116226	BRD-K69608737	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
116265	BRD-K69608737	PC3	3.33 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.6

Summary