CMap Candidate Details
Structure:
| CMap ID: | C05190 |
| Pert ID: | BRD-K26667523 |
| Compound Name: | TAK-733 |
| Targets: | MAP2K1 |
| MoA: | MEK inhibitor |
| SMILES: | Cn1c2ncn(C[C@@H](O)CO)c(=O)c2c(Nc2ccc(I)cc2F)c(F)c1=O |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 121959 | BRD-K26667523 | HEK293 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122051 | BRD-K26667523 | HUVEC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122168 | BRD-K26667523 | PC3 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.18 | -0.61 | 0.0 |
| 122194 | BRD-K26667523 | THP1 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.21 | -0.7 | 0.03 |
| 130186 | BRD-K26667523 | A375 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130204 | BRD-K26667523 | A549 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130230 | BRD-K26667523 | HA1E | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130291 | BRD-K26667523 | HELA | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130319 | BRD-K26667523 | HT29 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.24 | -0.79 | 0.11 |
| 130352 | BRD-K26667523 | JURKAT | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130401 | BRD-K26667523 | MCF10A | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.23 | 0.82 | 0.1 |
| 130433 | BRD-K26667523 | MCF??7.00 | 0.74 uM | 24 h | 0.19 | 0.78 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130451 | BRD-K26667523 | MDAMB231 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.29 | 1.04 | 0.54 |
| 130523 | BRD-K26667523 | YAPC | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.32 | 1.13 | 0.8 |