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CMap Candidate Details

Structure:
CMap ID: C05198
Pert ID: BRD-K95142244
Compound Name: talazoparib
Targets: PARP2
MoA: PARP inhibitor
SMILES: Cn1ncnc1[C@@H]1[C@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90832 BRD-K95142244 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95567 BRD-K95142244 MCF??7.00 4 uM 48 h 0.19 0.81 0.0 0.0 0.0 0.0
95655 BRD-K95142244 U2OS 4 uM 48 h -0.23 -0.97 0.11 0.28 0.99 0.39
128385 BRD-K95142244 A549 10 uM 24 h -0.27 -1.12 0.39 0.0 0.0 0.0
128440 BRD-K95142244 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128550 BRD-K95142244 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128642 BRD-K95142244 MDAMB231 3.33 uM 24 h 0.25 1.04 0.16 0.0 0.0 0.0
128722 BRD-K95142244 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128768 BRD-K95142244 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136182 BRD-K95142244 A375 0.74 uM 24 h 0.2 0.82 0.0 0.0 0.0 0.0
136226 BRD-K95142244 HA1E 0.25 uM 24 h -0.25 -1.02 0.19 -0.28 -0.93 0.34
136263 BRD-K95142244 HELA 2.22 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
136291 BRD-K95142244 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136365 BRD-K95142244 PC3 0.74 uM 24 h 0.27 1.13 0.3 0.26 0.92 0.26
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).