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CMap Candidate Details

Structure:
CMap ID: C05202
Pert ID: BRD-K17555800
Compound Name: talmapimod
Targets: MAPK11|MAPK14
MoA: p38 MAPK inhibitor
SMILES: C[C@H]1CN([C@H](C)CN1Cc1ccc(F)cc1)C(=O)c1cc2c(cn(C)c2cc1Cl)C(=O)C(=O)N(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90624 BRD-K17555800 HCT116 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90658 BRD-K17555800 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95326 BRD-K17555800 A549 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
95368 BRD-K17555800 MCF??7.00 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
95438 BRD-K17555800 U2OS 10 uM 48 h 0.0 0.0 0.0 -0.26 -0.87 0.23
97982 BRD-K17555800 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98055 BRD-K17555800 P1A82 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120252 BRD-K17555800 A375 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.71
120351 BRD-K17555800 HELA 10 uM 24 h -0.21 -0.89 0.03 0.0 0.0 0.0
120490 BRD-K17555800 YAPC 0.37 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
128954 BRD-K17555800 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128977 BRD-K17555800 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.55
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).