CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00521
Pert ID:	BRD-K83186168
Compound Name:	AZD1981
Targets:	PTGDR2
MoA:	CRTH receptor antagonist
SMILES:	CC(=O)Nc1cccc2n(CC(O)=O)c(C)c(Sc3ccc(Cl)cc3)c12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125560	BRD-K83186168	A375	1.11 uM	24 h	-0.24	-1.02	0.17	0.25	0.88	0.19
125664	BRD-K83186168	HELA	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125688	BRD-K83186168	HT29	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125708	BRD-K83186168	HUVEC	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125761	BRD-K83186168	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.34	1.2	1.13
125816	BRD-K83186168	MCF??7.00	0.04 uM	24 h	0.26	1.09	0.23	-0.19	-0.64	0.01
125907	BRD-K83186168	YAPC	3.33 uM	24 h	0.22	0.93	0.05	0.0	0.0	0.0
133656	BRD-K83186168	A549	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133682	BRD-K83186168	HA1E	2.22 uM	24 h	0.25	1.03	0.13	0.0	0.0	0.0
133722	BRD-K83186168	HEK293	0.03 uM	24 h	0.0	0.0	0.0	-0.34	-1.14	1.03
133841	BRD-K83186168	MCF10A	0.03 uM	24 h	-0.34	-1.43	1.43	0.0	0.0	0.0
133898	BRD-K83186168	MDAMB231	0.74 uM	24 h	0.0	0.0	0.0	0.27	0.94	0.29
133932	BRD-K83186168	PC3	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133962	BRD-K83186168	THP1	0.03 uM	24 h	0.0	0.0	0.0	-0.37	-1.25	1.35

Summary