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CMap Candidate Details

Structure:
CMap ID: C05210
Pert ID: BRD-K93754473
Compound Name: tamoxifen
Targets: EBP|ESR1|ESR2|GPER1|PRKCA|PRKCB|PRKCD|PRKCE|PRKCG|PRKCI|PRKCQ|PRKCZ
MoA: estrogen receptor antagonist; selective estrogen receptor modulator (SERM)
SMILES: CC\C(c1ccccc1)=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1017 BRD-K93754473 CD34 12.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1055 BRD-K93754473 HL60 1.67 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1103 BRD-K93754473 U937 12.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9551 BRD-K93754473 AGS 30 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9859 BRD-K93754473 H1299 30 uM 6 h 0.0 0.0 0.0 0.3 1.08 0.65
10633 BRD-K93754473 HCT116 30 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11619 BRD-K93754473 NCIH2073 30 uM 6 h -0.34 -1.41 1.41 0.3 1.07 0.64
11876 BRD-K93754473 NCIH508 30 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12413 BRD-K93754473 NOMO1 30 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12908 BRD-K93754473 SW480 30 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13098 BRD-K93754473 THP1 30 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13709 BRD-K93754473 VCAP 30 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37764 BRD-K93754473 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38797 BRD-K93754473 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39022 BRD-K93754473 SKB 10 uM 24 h -0.22 -0.9 0.05 0.23 0.81 0.09
52874 BRD-K93754473 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91446 BRD-K93754473 HUH7 8 uM 72 h 0.22 0.92 0.04 0.26 0.92 0.25
95334 BRD-K93754473 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95430 BRD-K93754473 U2OS 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
98955 BRD-K93754473 NEU 10 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.3
99259 BRD-K93754473 NPC 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.05 0.71
117131 BRD-K93754473 HCC515 10 uM 24 h -0.25 -1.03 0.19 0.0 0.0 0.0
117225 BRD-K93754473 HT29 0.125 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
117265 BRD-K93754473 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117299 BRD-K93754473 PC3 10 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.59
128407 BRD-K93754473 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128431 BRD-K93754473 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.23 0.8 0.08
128541 BRD-K93754473 JURKAT 10 uM 24 h -0.2 -0.84 0.0 0.0 0.0 0.0
128590 BRD-K93754473 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
128634 BRD-K93754473 MDAMB231 0.125 uM 24 h 0.31 1.28 0.64 0.0 0.0 0.0
128761 BRD-K93754473 YAPC 10 uM 24 h 0.24 1.02 0.13 0.0 0.0 0.0
136174 BRD-K93754473 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136258 BRD-K93754473 HELA 0.25 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).