CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05239
Pert ID:	BRD-K11215326
Compound Name:	tazemetostat
Targets:	EZH2
MoA:	histone lysine methyltransferase inhibitor
SMILES:	CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
87295	BRD-K11215326	BJAB	0.5 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87380	BRD-K11215326	HBL1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87429	BRD-K11215326	K562	0.125 uM	24 h	0.0	0.0	0.0	-0.25	-0.86	0.21
87478	BRD-K11215326	KMS34	10 uM	24 h	0.0	0.0	0.0	0.22	0.78	0.07
87493	BRD-K11215326	MINO	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87581	BRD-K11215326	NALM6	0.04 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.67
87633	BRD-K11215326	OCILY10	10 uM	24 h	0.0	0.0	0.0	-0.23	-0.78	0.1
87682	BRD-K11215326	OCILY19	2.22 uM	24 h	0.19	0.77	0.0	0.0	0.0	0.0
87733	BRD-K11215326	OCILY3	0.04 uM	24 h	0.23	0.96	0.08	0.3	1.07	0.63
87781	BRD-K11215326	SKMEL5	10 uM	24 h	0.0	0.0	0.0	0.28	0.98	0.38
87797	BRD-K11215326	THP1	2.22 uM	24 h	0.0	0.0	0.0	-0.25	-0.86	0.2
87840	BRD-K11215326	TMD8	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
96217	BRD-K11215326	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
96292	BRD-K11215326	U2OS	0.37 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	1.0
96833	BRD-K11215326	A375	10 uM	24 h	0.0	0.0	0.0	0.2	0.71	0.02
96910	BRD-K11215326	PC3	10 uM	24 h	-0.24	-1.0	0.14	0.0	0.0	0.0

Summary