CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00527
Pert ID:	BRD-K84996356
Compound Name:	AZD3514
Targets:	AR
MoA:	androgen receptor modulator
SMILES:	CC(=O)N1CCN(CCOc2ccc(cc2)C2CCN(CC2)C2=Nn3c(CC2)nnc3C(F)(F)F)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
90615	BRD-K84996356	HCT116	3.33 uM	24 h	0.0	0.0	0.0	0.37	1.32	1.62
98073	BRD-K84996356	P1A82	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125567	BRD-K84996356	A375	10 uM	24 h	0.25	1.03	0.13	0.0	0.0	0.0
125605	BRD-K84996356	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125690	BRD-K84996356	HT29	10 uM	24 h	0.0	0.0	0.0	0.31	1.1	0.69
125716	BRD-K84996356	HUVEC	3.33 uM	24 h	0.27	1.13	0.3	-0.28	-0.93	0.35
125765	BRD-K84996356	JURKAT	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125844	BRD-K84996356	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125915	BRD-K84996356	YAPC	10 uM	24 h	0.23	0.95	0.06	-0.3	-1.02	0.6
133688	BRD-K84996356	HA1E	2.22 uM	24 h	0.0	0.0	0.0	-0.32	-1.07	0.76
133726	BRD-K84996356	HEK293	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133754	BRD-K84996356	HELA	2.22 uM	24 h	0.2	0.85	0.01	0.0	0.0	0.0
133845	BRD-K84996356	MCF10A	2.22 uM	24 h	0.35	1.47	1.12	-0.22	-0.75	0.06
133876	BRD-K84996356	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	-0.36	-1.21	1.24
133935	BRD-K84996356	PC3	2.22 uM	24 h	0.16	0.65	0.0	-0.32	-1.07	0.76
133966	BRD-K84996356	THP1	2.22 uM	24 h	0.0	0.0	0.0	-0.38	-1.27	1.44

Summary